abstract：BACKGROUND & AIMS:Dysbiosis of the gut microbiota is associated with increased levels of circulating lipopolysaccharide (LPS) and subsequent activation of systemic inflammation. Diet is an important modulator of the gut microbiome. We aimed to investigate whether circulating markers of gut-related inflammation, LPS bin...

journal_title：Atherosclerosis

authors： Awoyemi A,Trøseid M,Arnesen H,Solheim S,Seljeflot I

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of circular RNAs (circRNAs) in coronary artery disease (CAD) remains elusive. The aim of the present study was to profile circRNAs expression in CAD patients and assess diagnostics biomarkers for CAD. METHODS:The circRNA profiles of 24 CAD patients and 7 controls were assessed by microarra...

journal_title：Atherosclerosis

authors： Wang L,Shen C,Wang Y,Zou T,Zhu H,Lu X,Li L,Yang B,Chen J,Chen S,Lu X,Gu D

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Allergic asthma can accelerate atherosclerosis, a disease in which plaque is deposited onto arterial walls and that may lead to coronary artery disease (CAD). Eosinophils are the most important effector cells in allergic asthma and are likely to become novel biomarkers for risk stratification of pat...

journal_title：Atherosclerosis

authors： Gao S,Deng Y,Wu J,Zhang L,Deng F,Zhou J,Yuan Z,Wang L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:We recently showed that miR-223-3p on high-density lipoproteins (HDL) is exported to endothelial cells, where it inhibits inflammation. However, the origin of miR-223-3p on HDL is unknown. We hypothesize that HDL-associated miR-223-3p originates in myeloid cells and is exported to HDL in a scavenger...

journal_title：Atherosclerosis

authors： Cuesta Torres LF,Zhu W,Öhrling G,Larsson R,Patel M,Wiese CB,Rye KA,Vickers KC,Tabet F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The recently identified adiponectin paralogue C1q and tumor necrosis factor-related protein 1 (CTRP1) has been associated with obesity-linked disorders and coronary atherosclerosis. So far, the impact of circulating CTRP1 on the incidence of future cardiovascular events is unclear. Therefore, we aim...

journal_title：Atherosclerosis

authors： Muendlein A,Leiherer A,Saely C,Ebner J,Geiger K,Brandtner EM,Vonbank A,Fraunberger P,Drexel H

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The beneficial effect of statin therapy has been well established for both primary and secondary prevention of cardiovascular disease. Nevertheless, it remains under-used among patients with chronic kidney disease (CKD). We aimed to investigate the impact of statin therapy across a wide spectrum of ...

journal_title：Atherosclerosis

authors： Natanzon SS,Matetzky S,Beigel R,Iakobishvili Z,Goldenberg I,Shechter M,Acute Coronary Syndrome Israel Survey (ACSIS) investigators.

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Long non-coding RNAs (lncRNAs) have proven to be involved in the progression of atherosclerosis and dyslipidemia. In addition, vascular smooth muscle cells (VSMCs) phenotype switching, including VSMCs-derived foam cells formation, plays a key role in the pathogenesis of atherosclerosis. LncRNA ENST0...

journal_title：Atherosclerosis

authors： Cai C,Zhu H,Ning X,Li L,Yang B,Chen S,Wang L,Lu X,Gu D

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND AIMS:A recently identified locus for coronary artery disease (CAD) tagged by rs8042271 is in a region of tight linkage disequilibrium (LD) between 2 genes (MFGE8, ABHD2) previously linked to atherosclerosis. Here we have explored the regulatory framework of this region to identify its functional relation...

journal_title：Atherosclerosis

authors： Soubeyrand S,Nikpay M,Turner A,Dang AT,Herfkens M,Lau P,McPherson R

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND AIMS:It remains unclear how trans fatty acid (TFA) at low-level intake affect lipid levels and the development of acute coronary syndrome (ACS). The study aimed to investigate how plasma TFA composition differs between male patients with ACS and healthy men. METHODS:Plasma fatty acid (FA) composition (a...

journal_title：Atherosclerosis

authors： Koba S,Takao T,Shimizu F,Ogawa M,Ishii Y,Yokota Y,Furuyama F,Tsunoda F,Shoji M,Harris WS,Takada A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score wi...

journal_title：Atherosclerosis

authors： Mazidi M,Katsiki N,Mikhailidis DP,Banach M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidative stress-induced endothelial dysfunction is considered to exert a vital role in the development of atherosclerotic coronary heart disease (CHD). NRF2 is a key transcriptional factor against oxidative stress through activation of multiple ARE-mediated genes. Z-Lig is derived from the Ligustic...

journal_title：Atherosclerosis

authors： Zhu Y,Zhang Y,Huang X,Xie Y,Qu Y,Long H,Gu N,Jiang W

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND AIMS:High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present analysis was designed to investigate the association of LDL triglycerides with cardiovascular mortality and to explore possible mechanisms that may...

journal_title：Atherosclerosis

authors： Silbernagel G,Scharnagl H,Kleber ME,Delgado G,Stojakovic T,Laaksonen R,Erdmann J,Rankinen T,Bouchard C,Landmesser U,Schunkert H,März W,Grammer TB

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency may also influence platelet production at the level of its precursor c...

journal_title：Atherosclerosis

authors： Ouweneel AB,Hoekstra M,van der Wel EJ,Schaftenaar FH,Snip OSC,Hassan J,Korporaal SJA,Van Eck M

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Endothelium inflammation, which can lead to endothelial activation and dysfunction, is widely accepted as the major event in multiple vascular disorders. The lncRNA HOXA-AS2 was previously reported to be involved in multiple inflammation-linked cancers. However, the role of HOXA-AS2 in endothelium i...

journal_title：Atherosclerosis

authors： Zhu X,Liu Y,Yu J,Du J,Guo R,Feng Y,Zhong G,Jiang Y,Lin J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND AIMS:A small crypt in the Santissima Annunziata Church of Santa Maria della Scala Hospital in Siena (Italy) contained three well-preserved mummies, two of which, dated back to the 15th-16th century, were identified as Salimbene Capacci (1433-1497), Rector of the Hospital, and his wife, Margherita Sozzini...

journal_title：Atherosclerosis

authors： Gaeta R,Fornaciari A,Izzetti R,Caramella D,Giuffra V

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Clinical practice guidelines recommend specific statin doses for the primary and secondary prevention of cardiovascular disease. Little is known about how statin utilization and dosing have evolved over time in Hong Kong. The aim of this study was to describe trends in statin prevalence, initiation,...

journal_title：Atherosclerosis

authors： Blais JE,Chan EW,Law SWY,Mok MT,Huang D,Wong ICK,Siu CW

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIMS:A few studies examined association between familial hypercholesterolemia (FH) and atherosclerotic cardiovascular disease (ASCVD) in Asians with low levels of serum cholesterol. The objectives of this study were to estimate the prevalence of familial hypercholesterolemia phenotype (FH-P) and examined...

journal_title：Atherosclerosis

authors： Jung KJ,Koh H,Choi Y,Lee SJ,Ji E,Jee SH

更新日期：2018-11-01 00:00:00

abstract：:Atherosclerosis is a major underlying cause of ischemic heart diseases, ischemic stroke, and peripheral artery disease. Atherosclerotic plaque progression is characterized by chronic progressive inflammation of the arterial wall, endothelial cell dysfunction, and subendothelial lipoprotein retention. Incretin drugs, g...

journal_title：Atherosclerosis

authors： Gallego-Colon E,Wojakowski W,Francuz T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND AIMS:We examined whether the inflammation resolution mediator lipoxin A4 (LXA4) inhibits foam cell formation and oxidized low-density lipoprotein (oxLDL)-induced apoptotic signaling in macrophages and the role of circulating/local LXA4 biosynthesis in atherogenesis. METHODS:LXA4 levels were measured by ...

journal_title：Atherosclerosis

authors： Mai J,Liu W,Fang Y,Zhang S,Qiu Q,Yang Y,Wang X,Huang T,Zhang H,Xie Y,Lin M,Chen Y,Wang J

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Cardiovascular disease (CVD), including coronary artery disease and stroke/peripheral artery disease, is less commonly reported than venous thromboembolism in subjects with antiphospholipid antibodies (aPLs) and little is known about the association of CVD with adjusted Global AntiphosPholipid Syndr...

journal_title：Atherosclerosis

authors： Di Minno MND,Scalera A,Tufano A,Ambrosino P,Bettiol A,Silvestri E,Emmi G,Prisco D

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS:We included 6617 participants from...

journal_title：Atherosclerosis

authors： Cainzos-Achirica M,Enjuanes C,Greenland P,McEvoy JW,Cushman M,Dardari Z,Nasir K,Budoff MJ,Al-Mallah MH,Yeboah J,Miedema MD,Blumenthal RS,Comin-Colet J,Blaha MJ

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The...

journal_title：Atherosclerosis

authors： Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS:FH Canada has esta...

journal_title：Atherosclerosis

authors： Brunham LR,Ruel I,Khoury E,Hegele RA,Couture P,Bergeron J,Baass A,Dufour R,Francis GA,Cermakova L,Mancini GBJ,Brophy JM,Brisson D,Gaudet D,Genest J

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Although familial hypercholesterolemia (FH) can be effectively managed using cholesterol-lowering medication, patients often fall short of complete treatment adherence. Identifying the psychological factors associated with self-regulation of FH medication is important to inform interventions to maxi...

journal_title：Atherosclerosis

authors： Hagger MS,Hardcastle SJ,Hu M,Kwok S,Lin J,Nawawi HM,Pang J,Santos RD,Soran H,Su TC,Tomlinson B,Watts GF

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed. METHODS:We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T...

journal_title：Atherosclerosis

authors： Mancini GBJ,Boden WE,Brooks MM,Vlachos H,Chaitman BR,Frye R,Bittner V,Hartigan PM,Dagenais GR

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Collagen synthesis in vascular smooth muscle cells (VSMCs) is very important in atherosclerosis, as it affects plaque stability. In this study, we aim to assess whether miR-124-3p is involved in the collagen synthesis process in VSMCs and the role it might play in atherosclerotic development. METHO...

journal_title：Atherosclerosis

authors： Chen W,Yu F,Di M,Li M,Chen Y,Zhang Y,Liu X,Huang X,Zhang M

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Patients with hyperlipidemia who are unable to tolerate optimal statin therapy are at increased cardiovascular risk due to ongoing elevations in low-density lipoprotein cholesterol (LDL-C). The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid whe...

journal_title：Atherosclerosis

authors： Ballantyne CM,Banach M,Mancini GBJ,Lepor NE,Hanselman JC,Zhao X,Leiter LA

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) parallels the obesity epidemic and associates with components of the metabolic syndrome (MetS). Cholesterol efflux capacity (CEC) represents a key metric of high density lipoprotein (HDL) function which may predict atherosclerotic cardiovascular disease (CVD...

journal_title：Atherosclerosis

authors： van den Berg EH,Gruppen EG,Ebtehaj S,Bakker SJL,Tietge UJF,Dullaart RPF

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:A potential increased risk of cardiovascular events has been suggested for proton pump inhibitors (PPIs), the most commonly prescribed drugs for the management of upper gastrointestinal disorders. We aimed to estimate the risk of hospitalization for cardio/cerebrovascular (CV) events in a cohort of ...

journal_title：Atherosclerosis

authors： Casula M,Scotti L,Galimberti F,Mozzanica F,Tragni E,Corrao G,Catapano AL

更新日期：2018-10-01 00:00:00

abstract：:Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have ide...

journal_title：Atherosclerosis

authors： Cho KI,Sakuma I,Sohn IS,Jo SH,Koh KK

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:In Switzerland, the prevalence of familial hypercholesterolemia (FH) due to pathogenic apolipoprotein B-100 gene (APOB) variants was known, but not the prevalence of FH due to pathogenic low-density lipoprotein-receptor gene (LDLR) variants. Phenotypic differences (LDLR versus APOB) might affect the...

journal_title：Atherosclerosis

authors： Miserez AR,Martin FJ,Spirk D

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenu...

journal_title：Atherosclerosis

authors： Ganbaatar B,Fukuda D,Salim HM,Nishimoto S,Tanaka K,Higashikuni Y,Hirata Y,Yagi S,Soeki T,Sata M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The mechanisms involved in endothelial dysfunction in humans during aging are largely unknown at the level of conduit arteries. We aimed to asses the role of NO and CYP450 epoxygenases-derived epoxyeicosatrienoic acids (EETs) in the regulation of endothelium-dependent flow-mediated dilatation of con...

journal_title：Atherosclerosis

authors： Wils J,Djerada Z,Roca F,Duflot T,Iacob M,Remy-Jouet I,Joannides R,Bellien J

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Lipoprotein(a) (Lp(a)) is a causal risk factor for cardiovascular disorders including coronary heart disease and calcific aortic valve stenosis. Apolipoprotein(a) (apo(a)), the unique glycoprotein component of Lp(a), contains sequences homologous to plasminogen. Plasminogen activation is markedly ac...

journal_title：Atherosclerosis

authors： Romagnuolo R,Scipione CA,Bazzi ZA,Boffa MB,Koschinsky ML

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Dysregulation of long non-coding RNAs (lncRNAs) has been proven to be involved in the pathogenesis of coronary artery disease (CAD). However, it remains to be extensively explored. Thus, the present study aims to study expression patterns, biological functions, and diagnostic value of lncRNAs in CAD...

journal_title：Atherosclerosis

authors： Li L,Wang L,Li H,Han X,Chen S,Yang B,Hu Z,Zhu H,Cai C,Chen J,Li X,Huang J,Gu D

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients ...

journal_title：Atherosclerosis

authors： Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro and atherosclerosis susceptibility in vivo was invest...

journal_title：Atherosclerosis

authors： Nahon JE,Hoekstra M,Havik SR,Van Santbrink PJ,Dallinga-Thie GM,Kuivenhoven JA,Geerling JJ,Van Eck M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Left ventricular hypertrophy (LVH), assessed by electrocardiogram (ECG), is associated with increased risk for stroke. However, few studies that evaluated whether ECG-detected LVH predicts ischemic stroke severity and outcome. We aimed to evaluate these associations. METHODS:We prospectively studie...

journal_title：Atherosclerosis

authors： Tziomalos K,Sofogianni A,Angelopoulou SM,Christou K,Kostaki S,Papagianni M,Satsoglou S,Spanou M,Savopoulos C,Hatzitolios AI

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. ...

journal_title：Atherosclerosis

authors： do Vale GT,Simplicio JA,Gonzaga NA,Yokota R,Ribeiro AA,Casarini DE,de Martinis BS,Tirapelli CR

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Left-sided valvular calcification is associated with cardiovascular disease (CVD) morbidity and mortality. Resting heart rate (RHR) may influence valvular calcium progression through shear stress. Whether RHR, an established CVD risk factor, is associated with valvular calcium progression is unknown...

journal_title：Atherosclerosis

authors： Amoakwa K,Fashanu OE,Tibuakuu M,Zhao D,Guallar E,Whelton SP,O'Neal WT,Post WS,Budoff MJ,Michos ED

更新日期：2018-06-01 00:00:00